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3D Genetic Structure in Blood Cancer Important Beyond DNA Code Changes

Mar 23, 2020 - PR Newswire

PR Newswire

Children with aggressive blood cancers have differences - not just in the DNA code of their blood cells - but also in the heavily twisted protein superstructure that controls access to genes.

Led by researchers at NYU Grossman School of Medicine, a new study showed that whether T cell acute lymphoblastic leukemia takes off or worsens depends on structural changes in the layout of protein bundles called chromosomes. Upon receiving the right signal, this arrangement ...