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Novartis new analysis further shows durable and potent LDL-C reduction with inclisiran, an investigational first-in-class siRNA cholesterol-lowering treatment

Mar 28, 2020 - Thomson Reuters ONE
Mergers and Acquisitions

- Prespecified analysis of pooled data from ORION-9, -10 and -11 Phase III clinical trials shows inclisiran reduced low-density lipoprotein-cholesterol (LDL-C) by 51% at 17 months1

- Prespecified exploratory analysis based on safety reporting from the three trials, showed fewer major adverse cardiovascular events (MACE) with inclisiran compared to placebo1

- The data are consistent with LDL-C lowering as a strong surrogate for improved patient cardiovascular outcomes2 and reaffirms r...