Aly Shamji

Executive Director, Center for the Science of Therapeutics at The Broad Institute, Inc.

Aly Shamji

Aly Shamji

Executive Director, Center for the Science of Therapeutics at The Broad Institute, Inc.

Biography

Broad Institute,
Alykhan Shamji,
Executive Director,



Alykhan Shamji joined the Broad Institute in 2007 and now serves as the executive director of the institute’s Center for the Science of Therapeutics (CSofT). He works closely with Broad investigators to apply chemical biology approaches that advance the mission of the institute: accelerating the understanding and treatment of disease. He leads a research group in this area, and is responsible for administering specific CSofT activities and projects. Additionally, he oversees the financial and operational administration of the Chemical Biology Program, now part of CSofT.

Shamji’s work focuses on the discovery and characterization of small molecules that have the potential to impact disease research and medicine. Working with the scientific community, his group aims to understand the relationship between disease genetics, pathophysiology, and the response to small molecules, with the goal of defining and testing strategies for therapeutic intervention. His projects focus on cancer, diabetes, and inflammatory bowel disease.

Before joining the Broad, Shamji was a management consultant at the Boston Consulting Group, focusing on pharmaceuticals, clinical diagnostics, and strategic acquisitions. He received both his A.B. in biochemical sciences and his Ph.D. in biophysics from Harvard University.

Overview
Career Highlights

The Broad Institute, Inc.

RelSci Relationships

678

Number of Boards

1

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Co-Founder at Eli & Edythe Broad Foundation

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President & Director at The Broad Institute, Inc.

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Director, Genome Sequencing & Analysis Program at The Broad Institute, Inc.

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Director, Sponsored Research & Planning at The Broad Institute, Inc.

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Director, Genomic Sequencing Center for Infectious Diseases at The Broad Institute, Inc.

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Member, Editorial Board at CBE - Life Sciences Education

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Senior Director Genomics Platform at The Broad Institute, Inc.

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Director-Stanley Center for Psychiatric Research at The Broad Institute, Inc.

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Co-Founder at Celsius Therapeutics, Inc.

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Senior Scientific Advisor at Clarus Ventures LLC

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Aly Shamji
Executive Director, Center for the Science of Therapeutics at The Broad Institute, Inc.
Education
PhD in Biophysics

The oldest corporation in the Western Hemisphere is the Harvard Corporation, known formally as the President and Fellows of Harvard College. It is the smaller of Harvard’s two governing boards; the other is the Board of Overseers. Following are the members of the Harvard Corporation.

Career History
Executive Director, Center for the Science of Therapeutics
2007 - Current

The Broad Institute evolved from a decade of informal and successful research collaborations among scientists in the MIT and Harvard communities. In 1990, the Whitehead Institute/MIT Center for Genome Research (WICGR) was founded, and it soon became an international leader in the field of genomics and a flagship of the Human Genome Project. As early as 1995, WICGR scientists recognized the need to bring the power of genomics to the understanding of human disease. It launched pilot projects in genomic medicine, forming an unofficial collaborative network among scientists from across MIT and Harvard who pioneered new approaches to cancer and human genetics. In parallel, Harvard Medical School-based scientists established the Institute of Chemistry and Cell Biology (ICCB) in 1998, to facilitate the pursuit of chemical genetics as an academic discipline and a tool to further understand human biology and disease. In 2002, the ICCB was awarded an Initiative for Chemical Genetics (ICG) grant from the National Cancer Institute, and its successful Investigator-Initiated Screening Program facilitated small molecule screening projects for more than 80 research groups worldwide. These projects demonstrated the power of enabling scientists to collaborate to tackle the major challenges in molecular medicine. It was clear that a new type of formal organization was required — open, collaborative, interdisciplinary, and able to organize projects at any scale. In addition, it was important that the complementary expertise of the genomic scientists and the chemical biologists across MIT and Harvard be brought together in one place to drive the transformation of medicine with molecular knowledge. Discussions in 2002-2003 among Eli and Edythe Broad, MIT, Harvard and its affiliated hospitals, and the Whitehead Institute shaped the vision for this new institute. The extraordinary generosity of Eli and Edythe Broad, through their founding gift of $100 million (later doubled to $200 million) made it possible to formally announce the new institute in June 2003 and to launch it in May 2004. Less than four years after its launch, the Broads gave an unprecedented gift of $400 million in September 2008 to permanently endow the institute, providing long-term sustainability for its unique model of collaborative, inter-institutional research.

Management Consultant
Prior

The Boston Consulting Group, Inc. provides management consulting and business strategy advisory services. The firm specializes in big data and advanced analytics, change management, marketing and sales, people and organization, post merger integration and globalization. The company was founded by Bruce Doolin Henderson in 1963 and is headquartered in Boston, MA.

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