Mark S. George

Director, Brain Stimulation Laboratory at Medical University of South Carolina

Mark S. George

Mark S. George

Director, Brain Stimulation Laboratory at Medical University of South Carolina

Biography

As an undergraduate student in philosophy at Davidson College in Davidson, NC, Dr. George first began studying the relationship between mind and brain, or brain/behavior relationships. He has continued this interest throughout his career with a focus on using brain imaging and brain stimulation to understand depression and devise new treatments.

He received his medical degree from the Medical University of South Carolina in Charleston in 1985, where he continued with dual residencies in both neurology and psychiatry. He is board certified in both areas. Following his residency training he worked for one year (1990-91) as a Visiting Research Fellow in the Raymond Way Neuropsychiatry Research Group at the Institute of Neurology, Queen Square, London, England. During his fellowship he wrote one of the first textbooks in the new area of brain activation and imaging.

He then moved to Washington, DC, working with Dr. Robert Post in the Biological Psychiatry Branch of the Intramural National Institute of Mental Health (NIMH). During his 4 years at NIMH he was one of the first to use functional imaging (particularly oxygen PET) and discovered that specific brain regions change activity during normal emotions. He then started using imaging to understand brain changes that occur in depression and mania, a quest that he and many others are still pursuing. This imaging work directly led to his pioneering use of a non-invasive brain stimulation method, transcranial magnetic stimulation (TMS), as a probe of neuronal circuits regulating mood, and to clinical trials using TMS as an antidepressant. In 1993 while at the NIMH, he discovered that daily prefrontal rTMS over several weeks could treat depression and ever since he has worked to grow the science of TMS, both in terms of how it works in the brain, and in critically evaluating its therapeutic applications, especially in the area of treating depression. This was FDA approved in October, 2008. He has completed the pivotal study in this area with NIH funding and is now investigating its effectiveness in the VA population through a VA cooperative study.

In 1995 he moved back to Charleston and built the functional neuroimaging division and brain stimulation laboratories. This imaging group has grown into the MUSC Center for Advanced Imaging Research, which is now part of the SC Brain Imaging Center of Excellence. He continues to use imaging (particularly functional MRI) and non-invasive stimulation (TMS, or VNS), either separately or more recently in combination, to understand the brain regions involved in regulating emotion in health and disease. In June 1998 at MUSC, he also pioneered another new treatment for resistant depression, vagus nerve stimulation (VNS). This was FDA approved in 2006. He and his group have used MRI imaging to understand VNS brain effects.

He is a world expert in brain stimulation, and depression, and is the editor-in-chief of a new journal he launched with Elsevier in 2008 called, Brain Stimulation: Basic, Translation and Clinical Research in Neuromodulation.

He has been continuously funded by NIH and other funding agencies since his fellowships. He has received both a NARSAD Young Investigator and Independent Investigator Award to pursue TMS research in depression. He has received numerous international awards including the NARSAD Klerman Award (2000), NARSAD Falcone Award (2008) and the Lifetime Achievement Award (2007) given by the World Federation of Societies of Biological Psychiatry (WFSBP). In 2009 US News and World Report named him one of 14 ‘medical pioneers who are not holding back’. He is on several editorial review boards and NIH study sections, has published over 400 scientific articles or book chapters, and has written or edited 6 books.

Overview
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Co-Founder at Halo Neuro, Inc.

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Co-Founder at Halo Neuro, Inc.

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Director of Product Management at Google, Inc.

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Director-Neurorehabilitation Clinic at UCSF Medical Center

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Advisor at Halo Neuro, Inc.

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Co-Founder & Chief Executive Officer at Lattice Engines, Inc.

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Head of Mobile at Facebook, Inc.

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Founder at The Coalition for Green Capital

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Co-Founder at Tal Medical, Inc.

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Co-Founder & Chief Executive Officer at Oscar Health Agency, Inc.

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Mark S. George
Director, Brain Stimulation Laboratory at Medical University of South Carolina
Education
MD Medicine

Founded over 180 years ago, the Medical University of South Carolina has an impressive history of medical education. Though it began as a small, privately owned institution, MUSC has grown into a substantial public university, comprised of many colleges: *College of Medicine *College of Pharmacy *College of Nursing *College of Graduate Studies *College of Dental Medicine *College of Health Professions The College of Medicine is the oldest of these schools, offering a four-year M.D. program. The College of Graduate Studies features the most varied academics, with programs in Neuroscience, Microbiology and Immunology and Environmental Sciences, to name a few. The other colleges offer a combination of bachelor’s, master’s and doctoral programs. Because of the Medical University of South Carolina’s vast academic offerings, admissions requirements vary quite a bit from program to program. Generally speaking, master’s and doctoral degrees require a bachelor’s degree to apply. For specific admissions procedures, consult the university’s bulletin. MUSC offers several financial aid opportunities, including federal grants and loans, work-study and institutional scholarships. The state of South Carolina funds many scholarships as well, including the South Carolina LIFE Scholarship.

B.A. Philosophy

Davidson is a highly selective independent liberal arts college for 1,920 students located 20 minutes north of Charlotte in Davidson, N.C. Since its establishment in 1837 by Presbyterians, the college has graduated 23 Rhodes Scholars and is consistently regarded as one of the top liberal arts colleges in the country. Through The Davidson Trust, the college became the first liberal arts institution in the nation to replace loans with grants in all financial aid packages, giving all students the opportunity to graduate debt-free. Davidson competes in NCAA athletics at the Division I level, and a longstanding Honor Code is central to student life at the college.

Career History
Editor-in-Chief-Brain Stimulation
Current

Elsevier BV provides information solutions. It offers web-based, digital solutions such as ScienceDirect, Scopus, Elsevier Research Intelligence, and ClinicalKey. The firm also publishes journals such as The Lancet and Cell. The company was founded in 1880 and is headquartered in Amsterdam, the Netherlands.

Director, Brain Stimulation Laboratory
Current

Founded over 180 years ago, the Medical University of South Carolina has an impressive history of medical education. Though it began as a small, privately owned institution, MUSC has grown into a substantial public university, comprised of many colleges: *College of Medicine *College of Pharmacy *College of Nursing *College of Graduate Studies *College of Dental Medicine *College of Health Professions The College of Medicine is the oldest of these schools, offering a four-year M.D. program. The College of Graduate Studies features the most varied academics, with programs in Neuroscience, Microbiology and Immunology and Environmental Sciences, to name a few. The other colleges offer a combination of bachelor’s, master’s and doctoral programs. Because of the Medical University of South Carolina’s vast academic offerings, admissions requirements vary quite a bit from program to program. Generally speaking, master’s and doctoral degrees require a bachelor’s degree to apply. For specific admissions procedures, consult the university’s bulletin. MUSC offers several financial aid opportunities, including federal grants and loans, work-study and institutional scholarships. The state of South Carolina funds many scholarships as well, including the South Carolina LIFE Scholarship.

Advisor
Current

Halo Neuroscience is a venture backed medtech company based in San Francisco. Halo is developing a novel, simple, and powerful neuroscience-based technology for enhancing brain performance for the healthy and impaired.

Boards & Committees
Board Advisor
Current

Halo Neuroscience is a venture backed medtech company based in San Francisco. Halo is developing a novel, simple, and powerful neuroscience-based technology for enhancing brain performance for the healthy and impaired.

Member, Scientific Advisory Board
Current

Tal Medical, Inc. operates as a clinical stage medical device company. It develops novel, non contact, neuromodulatory devices for the treatment of psychiatric and neurological disorders. The firm focuses on the development of LFMS for the treatment of major depressive disorder and bipolar depression. The company was founded by Daphne Zohar, Steven Marc Paul, Andrew Miller, Eric Elenko and Nessan Bermingham in 2010 and is headquartered in Boston, MA.

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