Nitin Baliga

Senior Vice President, Director & Professor at Institute for Systems Biology

Nitin Baliga

Nitin Baliga

Senior Vice President, Director & Professor at Institute for Systems Biology

Biography

Nitin Baliga leads a cross-disciplinary team of scientists to address complex problems relevant to global health, personalized medicine, energy, and environment. His team uses a systems approach to construct predictive models of cellular and molecular networks within pathogens, cancer cells, and environmental microbes to enable biotechnologies to overcome drug resistance, find new drugs, predict consequence of climate change, and manufacture biorenewables. Dr. Baliga is also actively engaged in science education, and is passionate about developing and disseminating current science curriculum and authentic cross-disciplinary practices to schools. His contributions to HS education have had worldwide impact, and have won awards including the Alvin J. Thompson award. As a Professor at the Institute for Systems Biology, he was one of the founding members, and currently serves as the Director and Senior Vice President.

Dr. Baliga did his early schooling in Mumbai, India, where he received a B.Sc. in Microbiology (1992) from Ruia College within the Mumbai University system. In 1992, Dr. Baliga entered a national competition and won the highly coveted Central Government of India sponsored Department of Biotechnology studentship, which supported his graduate studies in Marine Biotechnology at Goa University. After getting a M.Sc. in Marine Biotechnology in 1994, Dr. Baliga won the prestigious Council for Scientific and Industrial Research fellowship through another Central Government of India-sponsored national competition. After completing his Ph.D. in Microbiology in 2000 at the University of Massachusetts at Amherst, Dr. Baliga moved to Seattle for postdoctoral training with Dr. Leroy Hood at the Institute for Systems Biology.

In 2007, Dr. Baliga published a landmark paper that demonstrated how to accurately predict the response of an organism to a new environment. This breakthrough was made possible by a suite of technologies, experimental strategies and computational tools that Dr. Baliga and his team developed to reverse engineer the complete gene regulatory network of a free-living organism. This study uncovered the theory and fundamental principles that underlie the evolution and predictability of biological responses.

Applying this approach to environmental issues, Dr. Baliga has discovered how some extremophiles might explore life in a new environment, revised a >5 decade old “operon” paradigm of gene regulation in prokaryotes, discovered diurnal anticipatory behavior in archaea, uncovered the role of programmed cell death in unicellular chlorophytes, elucidated how cells maintain copper ions at a safe concentration and discovered the role of RNases in adaptation to rapid environmental changes. Together with collaborators at the University of Washington, and the Lawrence Berkeley Laboratories, he is now elucidating the biological networks underlying response to ocean acidification, social interactions, and fuel production in microbes.

Dr. Baliga has also expanded his research program to complex human disease to elucidate dysfunctional networks in cancers and the basis for latency, drug tolerance, and altered immune responses in TB infections. His work has identified regulatory drivers across multiple cancers, and are aiding academic organizations and pharmaceutical companies in drug target discovery, drug repositioning, and combinatorial therapeutics. Dr. Baliga’s work has been published in top international journals including Cell, Science and Nature. He has been invited to the Google SciFoo Camp, and has been profiled by The Scientist, Genome Web, Wired Magazine, Genetic Engineering News, Ars Technica, Xconomy, and Nature Methods, among many others. Research in Dr. Baliga’s laboratory has been supported by the National Science Foundation, National Institutes of Health, NASA, Department of Energy, and the Department of Defense. He is the Section Editor of BMC Systems Biology and Nature Scientific Data, serves on scientific advisory boards of numerous academic and industrial organizations, and been instrumental in research program planning for the NSF and DOE.

Dr. Baliga has also made transformative contributions to science education. He founded the Systems Education Experiences (SEE) program that has offered internship opportunities to dozens of students and teachers from underrepresented groups and of disadvantaged backgrounds. Science curriculum developed by Dr. Baliga’s SEE program has impacted >2 million students in over one hundred countries.

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Co-Founder at Arivale, Inc.

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Co-Founder at CODONiS, Inc.

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Scientist at Institute for Systems Biology

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Senior Manager at IBM Watson Research Center

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Interim Chief Medical Officer at Swedish Health Services

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President at Touchstone Corp.

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Chief Quality Officer at The Permanente Federation LLC

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Former Senior Vice President & Chief Technical Officer, Advanced Strategies & Policy at Microsoft Corporation

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Co-Founder at Washington Research Foundation

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Professional at Complete Genomics, Inc.

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Nitin Baliga
Senior Vice President, Director & Professor at Institute for Systems Biology
Education
Class of 2000

UMass Amherst, the flagship campus of the University of Massachusetts system, sits on nearly 1,450-acres in the scenic Pioneer Valley of Western Massachusetts, 90 miles from Boston and 175 miles from New York City. The campus provides a rich cultural environment in a rural setting close to major urban centers.

Class of 1994

Goa University, established in June 1985 by an Act of Goa Government, is located on a picturesque campus spread over 427.49 acres area

Class of 1992

The University of Mumbai (known earlier as University of Bombay) is one of the oldest and premier Universities in India. It was established in 1857 consequent upon "Wood's Education Dispatch", and it is one amongst the first three Universities in India.

Career History
Senior Vice President, Director & Professor
2005 - Current

The Institute for Systems Biology operates as a nonprofit biomedical research organization. It develops a systems approach to characterize, predict, and manipulate state transitions in biological system. The company was founded by Leroy E. Hood, Ruedi Aebersold and Alan Aderem in 2000 and is headquartered in Seattle, WA.

Boards & Committees
Director & Senior Vice President
2005 - Prior

The Institute for Systems Biology operates as a nonprofit biomedical research organization. It develops a systems approach to characterize, predict, and manipulate state transitions in biological system. The company was founded by Leroy E. Hood, Ruedi Aebersold and Alan Aderem in 2000 and is headquartered in Seattle, WA.

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